Joe Marler will miss the first half of the Six Nations after suffering a lower leg fracture.
The 26-year-old has been ruled out for up to five weeks.
With Mako Vunipola also injured, England coach Eddie Jones may be forced to start rookie prop Ellis Genge in the Six Nations.
England will also be without injured flank Chris Robshaw (shoulder) and centre Manu Tuilagi (knee).
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