Juan Martín Hernández will start at flyhalf after Nicolás Sánchez has been ruled out of Argentina's Test against England at Twickenham on Saturday.
Sanchez picked up an injury in Los Pumas' 19-16 defeat against Scotland last week, forcing him to sit out their final Test of the season. In his absence, Hernández will shift to No 10 with Santiago Gonzalez Iglesias coming in to the starting lineup at inside centre.
Coach Daniel Hourcade opted to rotate his scrumhalf, with Tomás Cubelli starting and Martín Landajo reverting to the bench.
In the pack, influential No 8 Facundo Isa is dropped and his place is taken by Leonardo Senatore.
Argentina – 15 Joaquín Tuculet, 14 Matías Orlando, 13 Matías Moroni, 12 Santiago Gonzalez Iglesias, 11 Santiago Cordero, 10 Juan Martín Hernández, 9 Tomás Cubell, 8 Leonardo Senatore, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Matías Alemanno, 4 Guido Petti, 3 Ramiro Herrera, 2 Agustín Creevy (c), 1 Lucas Noguera.
Subs: 16 Julián Montoya, 17 Santiago García Botta, 18 Enrique Pieretto, 19 Facundo Isa, 20 Tomás Lezana, 21 Martín Landajo, 22 Jeronimo de la Fuente, 23 Juan Pablo Estelles.
Photo: Paul Ellis/Getty Images