Peter Horne will start at inside centre in one of four changes to Scotland's starting lineup for Sunday's quarter-final against Australia at Twickenham.
Horne graduates from the bench to partner Glasgow Warriors teammate Mark Bennett in midfield, at the expense of Matt Scott, who drops out of the match 23 altogether.
In the pack, suspended pair Jonny Gray and Ross Ford are replaced by Tim Swinson and Fraser Brown at No 5 lock and hooker, respectively.
Elsewhere, Blair Cowan comes in for Ryan Wilson at blindside flank, to complete the back row with John Hardie and Dave Denton.
New additions to bench include Kevin Bryce, Alasdair Strokosch and Richie Vernon.
Scotland – 15 Stuart Hogg, 14 Sean Maitland, 13 Mark Bennett, 12 Peter Horne, 11 Tommy Seymour, 10 Finn Russell, 9 Greig Laidlaw (c), 8 David Denton, 7 John Hardie, 6 Blair Cowan, 5 Richie Gray, 4 Tim Swinson, 3 WP Nel, 2 Fraser, 1 Alasdair Dickinson.
Subs: 16 Kevin Bryce, 17 Gordon Reid, 18 Jon Welsh, 19 Alasdair Strokosch, 20 Josh Strauss, 21 Henry Pyrgos, 22 Richie Vernon, 23 Sean Lamont.
Photo: David Rogers/Getty Images