Francois Venter suffered a hamstring tear last weekend which could rule him out of the Cheetahs' match against the Sunwolves in Tokyo on Saturday.
Kings captain Schalk Ferreira suffered a bicep injury in his side's 19-17 defeat against the Sharks in Durban on Saturday.
Bok flank Marcell Coetzee suffered yet another knee injury during Ulster's 68-21 win against Zebre on Saturday.
Scotland loose forward Josh Strauss will miss the remainder of the Six Nations championship after sustaining a kidney injury against France last Sunday.
Bok prop Julian Redelinghuys is optimistic about a return to rugby despite doctors advising him against playing again.
Ruan Combrinck successfully underwent a shoulder operation on Wednesday, but is set to miss the start of the 2017 Super Rugby season.
Hurricanes duo Blade Thomson and Jeff Toomaga-Allen have been ruled out for the remainder of the Super Rugby tournament.
Warren Whiteley has been ruled out of action for six weeks after suffering a shoulder injury in Port Elizabeth.
Stormers co-captain Juan de Jongh will miss his team's clash with the Bulls at Loftus on Saturday.
Bulls centre Burger Odendaal will be sidelined for at least four weeks after suffering a quad injury against the Cheetahs.