Adam Byrne will make his Test debut on the right wing for Ireland against Argentina in Dublin on Saturday.
Rob Kearney is at fullback and Jacob Stockdale on the other wing.
Chris Farrell, who made his debut against Fiji last week, is paired in the midfield with Bundee Aki, who got his first start against the Springboks.
Johnny Sexton and Conor Murray resume their partnership in the halfbacks.
Rory Best returns to captain the team and is joined in the front row by Cian Healy and Tadhg Furlong, while James Ryan starts in the second row with Iain Henderson.
Peter O’Mahony, Sean O’Brien and CJ Stander return to the back row.
Ireland – 15 Rob Kearney, 14 Adam Byrne, 13 Chris Farrell, 12 Bundee Aki, 11 Jacob Stockdale, 10 Johnny Sexton, 9 Conor Murray, 8 CJ Stander, 7 Sean O’Brien, 6 Peter O’Mahony, 5 Iain Henderson, 4 James Ryan, 3 Tadhg Furlong, 2 Rory Best (c), 1 Cian Healy.
Subs: 16 James Tracy, 17 Dave Kilcoyne, 18 John Ryan, 19 Devin Toner, 20 Rhys Ruddock, 21 Luke McGrath, 22 Ian Keatley, 23 Andrew Conway.