Flank Rodrigo Bruni and prop Mayco Vivas will make their Vodacom Super Rugby debuts for the Jaguares against the Lions in Buenos Aires on Saturday.
Coach Gonzalo Quesada surprised with his selection of both Bruni and Vivas ahead of Test internationals Marcos Kremer and Juan Pablo Zeiss, who will play off the bench.
The rest of the match-day squad is pretty much as expected, with Joaquín Díaz Bonilla claiming the No 10 jersey following the departure of Nicolás Sánchez.
Centre Jerónimo de le Fuente has been named as captain for the 2019 season, taking over that responsibility from Pablo Matero.
Jaguares – 15 Joaquín Tuculet, 14 Bautista Delguy, 13 Matías Orlando, 12 Jerónimo de le Fuente (c), 11 Ramiro Moyano, 10 Joaquín Díaz Bonilla, 9 Gonzalo Bertranou, 8 Javier Ortega Desio, 7 Rodrigo Bruni, 6 Pablo Matera, 5 Tomás Lavanini, 4 Guido Petti, 3 Santiago Medrano, 2 Agustín Creevy, 1 Mayo Vivas.
Subs: 16 Julián Montoya, 17 Juan Pablo Zeiss, 18 Enrique Pieretto, 19 Matías Alemanno, 20 Marcos Kremer, 21 Martín Landajo, 22 Juan Cruz Mallía, 23 Matías Moroni.