Lyon and La Rochelle both progressed to the Top 14 semi-finals after claiming wins over Montpellier and Racing 92 respectively.
Montpellier beat Pau 24-15, while there were also wins for Lyon, Stade Français, Perpignan, Clermont and Racing 92 in the French Top 14.
Montpellier flyhalf Johan Goosen has been ruled out for up to six weeks with a foot injury.
Perpignan broke a 15-match losing streak by beating Montpellier 28-10, while there were also French Top 14 wins for Clermont, Castres, Lyon, Agen, La Rochelle and Toulouse.
Edinburgh beat Montpellier 19-10 to finish top of Pool 5 and secure a home quarter-final in the European Champions Cup, while there was also a win for Toulon on Friday.
Jacques du Plessis scored twice to help Montpellier beat Pau 41-13, while there were also French Top 14 wins for Lyon, Stade Français, La Rochelle, Bordeaux and Toulouse.
SARugbymag.co.za looks back at the past weekend’s European Champions and Challenge Cup matches involving South African players.
Jan Serfontein scored a try in Montpellier’s 34-13 win over Toulon, while there were also European Champions Cup wins for Racing 92 and Edinburgh on Sunday.
Ruan Pienaar and Frans Steyn scored tries as Montpellier beat Agen 18-13, while there were also Top 14 wins for Clermont, Toulouse, Bordeaux-Begles, Castres, Racing 92 and La Rochelle.
Montpellier has confirmed that utility back Frans Steyn has regained fitness and will be available for selection this weekend against Agen.