The uncapped duo of Luther Burrell and Jack Nowell have been named in the starting XV for England's Six Nations opener against France in Paris on Saturday.
Stade Français flyhalf Jules Plisson will earn his first Test cap when he starts for France against England in Paris.
Keep an eye on these players during the European tournament, which kicks off this weekend.
Scotland have made four changes to their starting XV and a further positional switch for their opening Six Nations match against Ireland in Dublin on Sunday.
Alun Wyn Jones will captain an experienced Wales side as they begin the defence of their Six Nations crown against Italy at the Millennium Stadium on Saturday.
Kelly Brown is confident a once debilitating stammer will have no bearing on his ability to lead the side in this season's Six Nations.
France coach Philippe Saint-André has taken a conservative line as he tries to win back French pride in the Six Nations, which kicks off on 1 February.
France's Six Nations hopes have been dealt a seismic blow with the news that captain Thierry Dusautoir will miss the tournament.
Uncapped winger Dougie Fife has been named in the 36-man squad for Scotland’s Six Nations campaign.
Centre Manu Tuilagi could be available for England’s final two Six Nations games after overcoming his injury.