Michael Hooper's battle with Jack Lam will prove pivotal in deciding who comes out on top when the Waratahs face the Hurricanes in Sydney on Saturday.
Elton Jantjies will make just his second start this season when the Lions take on the Chiefs in Hamilton on Saturday.
Richie McCaw will make his return to Super Rugby for the Crusaders' clash against the Brumbies in Christchurch on Saturday.
Bismarck du Plessis will lend the Sharks some much needed grunt in a match-shaping breakdown battle against the Rebels in Melbourne this Friday.
Quade Cooper will make his 100th Super Rugby appearance for the Reds against the Blues at Eden Park on Friday.
Richie McCaw will start in the No 6 jersey for the Crusaders against the Brumbies in Christchurch on Saturday.
Handré Pollard and William Small-Smith will make their first Vodacom Super Rugby starts for the Bulls against the Cheetahs at Loftus on Saturday.
The Reds have made four changes to their starting XV for their match against the Blues at Eden Park on Friday.
The Cheetahs have made three changes to their bench for Saturday's match against the Bulls at Loftus on Saturday.