Jano Vermaak and Pieter-Steph du Toit will earn their first Super Rugby caps for the Stormers against the Bulls at Newlands on Saturday.
Vermaak will combine with young Rob du Preez as the 9-10 pairing, while Du Toit will slot in alongside Eben Etzebeth in the second row.
Juan de Jongh and Johnny Kotze will do duty in the midfield, with Kobus van Wyk, Dillyn Lleyds and Cheslin Kolbe making up the back three.
Nizaam Carr and Schalk Burger will start at eighthman and blindside flank respectively, while Sikhumbuzo Notshe starts ahead of Siya Kolisi, who will make his return from injury off the bench.
Similarly, co-captain Frans Malherbe has been named among the replacements, with Vincent Koch, Bongi Mbonambi and Oli Kebble lining up in the front row.