The uncapped duo of Luther Burrell and Jack Nowell have been named in the starting XV for England's Six Nations opener against France in Paris on Saturday.
Jonny May has been given the No 11 jersey, while Danny Care moves back into the starting line-up at scrumhalf.
While four of the backline are changed from the team that started against New Zealand, the pack remains unchanged.
Former Sharks centre Brad Barritt is on the bench as cover for the midfield.
England – 15 Mike Brown, 14 Jack Nowell, 13 Luther Burrell, 12 Billy Twelvetrees, 11 Jonny May, 10 Owen Farrell, 9 Danny Care, 8 Billy Vunipola, 7 Chris Robshaw (c), 6 Tom Wood, 5 Courtney Lawes, 4 Joe Launchbury, 3 Dan Cole, 2 Dylan Hartley, 1 Joe Marler.
Subs: 16 Tom Youngs, 17 Mako Vunipola, 18 Henry Thomas, 19 Dave Attwood, 20 Ben Morgan, 21 Lee Dickson, 22 Brad Barritt, 23 Alex Goode.