Owen Farrell will captain England from flyhalf on his return from a ban for a dangerous tackle in the World Cup match against minnows Chile.
Farrell, who has been banned since last month’s warm-up victory over Wales, is one of 12 changes head coach Steve Borthwick has made for Saturday’s Pool D game in Lille.
The Saracens playmaker replaces the in-form George Ford for unbeaten England with Marcus Smith starting at fullback.
MORE: Farrell denies Bok clash is must-win
“One of the many great things about the Rugby World Cup is that the tournament provides an excellent opportunity to play against teams that we rarely have a chance to see,” Borthwick said in a statement.
“It is for that reason that we are particularly looking forward to testing ourselves against Chile on Saturday.
“Having watched our next opponent closely, we know that we will have to prepare and play well against a committed Chile team.
“As we head to the next round, it is only right that I once again pay tribute to our excellent supporters who I know will be right behind us in Lille this weekend,” the former England skipper added.
It will be the first time in his career that Harlequins’ Smith, 24, has started at fullback for either club or country.
Elliot Daly moves to centre from the No 15 shirt, Lewis Ludlam is now at No 8 and tighthead prop Kyle Sinckler are the three players to keep their spot.
Ford is named on the bench along with four fellow starters — prop Joe Marler, lock Ollie Chessum, back-rower Ben Earl and centre Joe Marchant — from last Sunday’s victory over Japan.
England end their group campaign by facing Samoa in Lille on October 7.
WATCH: Why Boks will beat Ireland
England — 15 Marcus Smith; 14 Henry Arundell, 13 Elliot Daly, 12 Ollie Lawrence, 11 Max Malins; 10 Owen Farrell (c), 9 Danny Care; 8 Billy Vunipola, 7 Jack Willis, 6 Lewis Ludlam; 5 George Martin, 4 David Ribbans; 3 Kyle Sinckler, 2 Theo Dan, 1 Bevan Rodd.
Subs: 16 Jack Walker, 17 Joe Marler, 18 Will Stuart, 19 Ollie Chessum, 20 Ben Earl, 21 Ben Youngs, 22 George Ford, 23 Joe Marchant.
Photo: Paul Harding/Getty Images