Joe Pietersen will start at flyhalf for the Cheetahs against the Sharks at Kings Park on Saturday.
The former Stormers fullback has got the nod ahead of Willie du Plessis, who is on the bench.
Clayton Blommetjies and Raymond Rhule have been named on the wings, with Springbok Cornal Hendricks among the substitutes.
The Cheetahs will be captained by lock Francois Uys.
Bok flank Heinrich Brüssow is being rested this weekend having only just returned from Japan.
Cheetahs – 15 Willie le Roux, 14 Clayton Blommetjies, 13 Francois Venter, 12 Michael van der Spuy, 11 Raymond Rhule, 10 Joe Pietersen, 9 Sarel Pretorius, 8 Willie Britz, 7 Oupa Mohoje, 6 Jean Cook, 5 Francois Uys (c), 4 Lodewyk de Jager, 3 Coenie Oosthuizen, 2 Torsten van Jaarsveld, 1 Danie Minnie.
Subs: 16 Stephan Coetzee, 17 BG Uys, 18 Maks van Dyk, 19 Carl Wegner, 20 Boom Prinsloo, 21 Tian Meyer, 22 Willie du Plessis, 23 Cornal Hendricks.