Coach Esteban Meneses has made two changes to the Uruguay starting XV for their second Pool A match against Italy in Nice on Wednesday.
German Kessler comes in at hooker and Gaston Mieres onto the wing, while there are 13 survivors in the match-day 23 from the last time the two sides played, in 2021.
Italy kicked off their World Cup campaign with a 52-8 victory over Namibia, while the Uruguayans lost 27-12 against France on Thursday.
Uruguay – 15 Baltazar Amaya, 14 Gaston Mieres, 13 Tomas Inciarte, 12 Andres Vilaseca (c), 11 Nicolas Freitas, 10 Felipe Etcheverry, 9 Santiago Arata, 8 Manuel Diana, 7 Santiago Civetta, 6 Manuel Ardao, 5 Manuel Leindekar, 4 Felipe Aliaga, 3 Ignacio Peculo, 2 German Kessler, 1 Mateo Sanguinetti.
Subs: Guillermo Pujadas, Facundo Gattas, Diego Arbelo, Ignacio Dotti, Carlos Deus, Agustin Ormaechea, Felipe Berchesi, Bautista Basso
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Photo: Franck Fife/AFP