Wales wing Alex Cuthbert has been ruled out of the third Test and series decider against the Springboks in Cape Town on Saturday.
Recalled for the second Test in Bloemfontein last weekend, Cuthbert lasted only 17 minutes before suffering a shoulder injury and being replaced by Josh Adams, who set up a dramatic 13-12 victory by scoring a late try.
The Welsh Rugby Union said no replacement will be flown to South Africa, with Adams set to be included when the team is named on Thursday.
There are fitness doubts about captain and flyhalf Dan Biggar (shoulder) and tighthead prop Dillon Lewis, who left the field and was later seen with an arm in a sling.
Gareth Anscombe, whose 79th-minute touchline conversion won the Bloemfontein Test, is expected to start if Biggar cannot play.
Should Lewis be ruled out, Sam Wainwright, who made his Test debut off the bench last week, is likely to make the starting lineup with uncapped 21-year-old Harri O’Connor the only other available specialist tighthead, though veteran loosehead Wyn Jones may be asked to moonlight on the right side of the front row.
The Springboks are set to name their match-day squad on Tuesday.
© Agence France-Presse