Mike Phillips and Dan Biggar will start in the halfbacks against Scotland in Cardiff this Saturday.
Coach Warren Gatland has also picked Liam Williams at fullback to replace the injured Leigh Halfpenny. The Dragons' star No 15 sustained a campaign-ending shoulder injury in the defeat to England last weekend.
Changes to the pack see Ken Owens and Rhodri Jones starting in the front row, while Luke Charteris will start alongside Alun-Wyn Jones in the locks.
Wales – 15 Liam Williams, 14 Alex Cuthbert, 13 Jonathan Davies, 12 Jamie Roberts, 11 George North, 10 Dan Biggar, 9 Mike Phillips, 8 Taulupe Faletau, 7 Sam Warburton (c), 6 Dan Lydiate, 5 Alun-Wyn Jones, 4 Luke Charteris, 3 Rhodri Jones, 2 Ken Owens, 1 Gethin Jenkins.
Subs: 16 Richard Hibbard, 17 Paul James, 18 Adam Jones, 19 Jake Ball, 20 Justin Tipuric, 21 Rhodri Williams, 22 Rhys Priestland, 23 James Hook.
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